Publications 2011

Andris-Widhopf, J., Steinberger, P., Fuller, R., Rader, C. & Barbas, C. F., 3rd. Generation of human scFv antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences. Cold Spring Harb Protoc 2011, doi:10.1101/pdb.prot065573 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21880816

Andris-Widhopf, J., Steinberger, P., Fuller, R., Rader, C. & Barbas, C. F., 3rd. Generation of human Fab antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences. Cold Spring Harb Protoc 2011, doi:10.1101/pdb.prot065565 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21880817

Collins, A., Hewitt, S. L., Chaumeil, J., Sellars, M., Micsinai, M., Allinne, J., Parisi, F., Nora, E. P., Bolland, D. J., Corcoran, A. E., Kluger, Y., Bosselut, R., Ellmeier, W., Chong, M. M., Littman, D. R. & Skok, J. A. RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation. Immunity 34, 303-314, doi:10.1016/j.immuni.2011.03.004 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21435585

Eisenwort, G., Jurkin, J., Yasmin, N., Bauer, T., Gesslbauer, B., Strobl, H. Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-β1-dependent human epidermal Langerhans cells.  J Invest Dermatol. 131(10):2049-57. doi: 10.1038/jid.2011.164. (2011).
Abstract: https://pubmed.ncbi.nlm.nih.gov/21677668/

Ellmeier, W., Abramova, A. & Schebesta, A. Tec family kinases: regulation of FcepsilonRI-mediated mast-cell activation. FEBS J 278, 1990-2000, doi:10.1111/j.1742-4658.2011.08073.x (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21362140

Gleixner, K. V., Mayerhofer, M., Cerny-Reiterer, S., Hormann, G., Rix, U., Bennett, K. L., Hadzijusufovic, E., Meyer, R. A., Pickl, W. F., Gotlib, J., Horny, H. P., Reiter, A., Mitterbauer-Hohendanner, G., Superti-Furga, G. & Valent, P. KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib. Blood 118, 1885-1898, doi:10.1182/blood-2010-06-289959 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21680801 

Grabmeier-Pfistershammer, K., Steinberger, P., Rieger, A., Leitner, J. & Kohrgruber, N. Identification of PD-1 as a unique marker for failing immune reconstitution in HIV-1-infected patients on treatment. J Acquir Immune Defic Syndr 56, 118-124, doi:10.1097/QAI.0b013e3181fbab9f (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20980914

Hassan, H., Sakaguchi, S., Tenno, M., Kopf, A., Boucheron, N., Carpenter, A. C., Egawa, T., Taniuchi, I. & Ellmeier, W. Cd8 enhancer E8I and Runx factors regulate CD8alpha expression in activated CD8+ T cells. Proc Natl Acad Sci U S A 108, 18330-18335, doi:10.1073/pnas.1105835108 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/22025728

Holzl, M. A., Hofer, J., Kovarik, J. J., Roggenbuck, D., Reinhold, D., Goihl, A., Gartner, M., Steinberger, P. & Zlabinger, G. J. The zymogen granule protein 2 (GP2) binds to scavenger receptor expressed on endothelial cells I (SREC-I). Cell Immunol 267, 88-93, doi:10.1016/j.cellimm.2010.12.001 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21190681 

Jahn-Schmid, B., Pickl, W. F. & Bohle, B. Interaction of allergens, major histocompatibility complex molecules, and T cell receptors: a 'menage a trois' that opens new avenues for therapeutic intervention in type I allergy. Int Arch Allergy Immunol 156, 27-42, doi:10.1159/000321904 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21447957

Kovarik, J. J., Tillinger, W., Hofer, J., Holzl, M. A., Heinzl, H., Saemann, M. D. & Zlabinger, G. J. Impaired anti-inflammatory efficacy of n-butyrate in patients with IBD. Eur J Clin Invest 41, 291-298, doi:10.1111/j.1365-2362.2010.02407.x (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21070220

Kueng, H. J., Schmetterer, K. G. & Pickl, W. F. Lipid rafts, pseudotyping, and virus-like particles: relevance of a novel, configurable, and modular antigen-presenting platform. Int Arch Allergy Immunol 154, 89-110, doi:10.1159/000320224 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/20733318 

Kuschei, W. M., Leitner, J., Majdic, O., Pickl, W. F., Zlabinger, G. J., Grabmeier-Pfistershammer, K. & Steinberger, P. Costimulatory signals potently modulate the T cell inhibitory capacity of the therapeutic CD11a antibody Efalizumab. Clin Immunol 139, 199-207, doi:10.1016/j.clim.2011.02.007 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21414849

Kuzmina, Z., Greinix, H. T., Weigl, R., Kormoczi, U., Rottal, A., Frantal, S., Eder, S. & Pickl, W. F. Significant differences in B-cell subpopulations characterize patients with chronic graft-versus-host disease-associated dysgammaglobulinemia. Blood 117, 2265-2274, doi:10.1182/blood-2010-07-295766 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21063025

Leitner, J., Drobits, K., Pickl, W. F., Majdic, O., Zlabinger, G. & Steinberger, P. The effects of Cyclosporine A and azathioprine on human T cells activated by different costimulatory signals. Immunol Lett 140, 74-80, doi:10.1016/j.imlet.2011.06.010 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21756939

Leitner, J., Grabmeier-Pfistershammer, K., Majdic, O., Zlabinger, G. & Steinberger, P. Interaction of antithymocyte globulins with dendritic cell antigens. Am J Transplant 11, 138-145, doi:10.1111/j.1600-6143.2010.03322.x (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21199353 

Matutes, E., Pickl, W. F., Van't Veer, M., Morilla, R., Swansbury, J., Strobl, H., Attarbaschi, A., Hopfinger, G., Ashley, S., Bene, M. C., Porwit, A., Orfao, A., Lemez, P., Schabath, R. & Ludwig, W. D. Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification. Blood 117, 3163-3171, doi:10.1182/blood-2010-10-314682 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21228332

Neunkirchner, A., Leb-Reichl, V. M., Schmetterer, K. G., Mutschlechner, S., Kueng, H. J., Haiderer, D., Schuch, K., Wallner, M., Jahn-Schmid, B., Bohle, B. & Pickl, W. F. Human TCR transgenic Bet v 1-specific Th1 cells suppress the effector function of Bet v 1-specific Th2 cells. J Immunol 187, 4077-4087, doi:10.4049/jimmunol.1003220 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21908735

Ormsby, T., Schlecker, E., Ferdin, J., Tessarz, A. S., Angelisova, P., Koprulu, A. D., Borte, M., Warnatz, K., Schulze, I., Ellmeier, W., Horejsi, V. & Cerwenka, A. Btk is a positive regulator in the TREM-1/DAP12 signaling pathway. Blood 118, 936-945, doi:10.1182/blood-2010-11-317016 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21659545

Peter, B., Gleixner, K. V., Cerny-Reiterer, S., Herrmann, H., Winter, V., Hadzijusufovic, E., Ferenc, V., Schuch, K., Mirkina, I., Horny, H. P., Pickl, W. F., Mullauer, L., Willmann, M. & Valent, P. Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536. Haematologica 96, 672-680, doi:10.3324/haematol.2010.031328 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21242189 

Schmetterer, K. G., Haiderer, D., Leb-Reichl, V. M., Neunkirchner, A., Jahn-Schmid, B., Kung, H. J., Schuch, K., Steinberger, P., Bohle, B. & Pickl, W. F. Bet v 1-specific T-cell receptor/forkhead box protein 3 transgenic T cells suppress Bet v 1-specific T-cell effector function in an activation-dependent manner. J Allergy Clin Immunol 127, 238-245, 245 e231-233, doi:10.1016/j.jaci.2010.10.023 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21211658 

Taniuchi, I. & Ellmeier, W. Transcriptional and epigenetic regulation of CD4/CD8 lineage choice. Adv Immunol 110, 71-110, doi:10.1016/B978-0-12-387663-8.00003-X (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21762816

Todoric, J., Strobl, B., Jais, A., Boucheron, N., Bayer, M., Amann, S., Lindroos, J., Teperino, R., Prager, G., Bilban, M., Ellmeier, W., Krempler, F., Muller, M., Wagner, O., Patsch, W., Pospisilik, J. A. & Esterbauer, H. Cross-talk between interferon-gamma and hedgehog signaling regulates adipogenesis. Diabetes 60, 1668-1676, doi:10.2337/db10-1628 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21536945 

Weichhart, T., Haidinger, M., Katholnig, K., Kopecky, C., Poglitsch, M., Lassnig, C., Rosner, M., Zlabinger, G. J., Hengstschlager, M., Muller, M., Horl, W. H. & Saemann, M. D. Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells. Blood 117, 4273-4283, doi:10.1182/blood-2010-09-310888 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21368289

Xanthos, D. N., Gaderer, S., Drdla, R., Nuro, E., Abramova, A., Ellmeier, W. & Sandkuhler, J. Central nervous system mast cells in peripheral inflammatory nociception. Mol Pain 7, 42, doi:10.1186/1744-8069-7-42 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21639869

Zeyda, M., Gollinger, K., Todoric, J., Kiefer, F. W., Keck, M., Aszmann, O., Prager, G., Zlabinger, G. J., Petzelbauer, P. & Stulnig, T. M. Osteopontin is an activator of human adipose tissue macrophages and directly affects adipocyte function. Endocrinology 152, 2219-2227, doi:10.1210/en.2010-1328 (2011).
Abstract: https://www.ncbi.nlm.nih.gov/pubmed/21467192