Nicole Boucheron, Group leader

Dr. Nicole Boucheron
Medizinische Universität Wien
Abteilung für Immunbiologie
Institut für Immunologie
Zentrum für Pathophysiologie, Infektiologie und Immunologie
Lazarettgasse 19, 3. Stock
1090 Wien 

Tel.: +43 (0)1 40160 - 33293
E-Mail: nicole.boucheron@meduniwien.ac.at
Laboratory homepage: www.meduniwien.ac.at/immunobiology

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Research Interests
Animal Diseases; Antigens, Differentiation, T-Lymphocyte; CD4-Positive T-Lymphocytes

T helper cell regulation

My main Research Interests are the activation, differentiation and modulation of T helper cells, as well as their role during immune responses. In particular I am interested in the fine-tuning of particular T helper subsets, as this was shown to have considerable impact on the effectiveness of an immune reaction during murine disease models. Naïve CD4+ T cells achieve this fine-tuning by sensing their environment. Signaling events as well as metabolic conditions connected to epigenetic mechanisms lead to the final identity of a particular T helper cell. As an example I identified Tec as a specific modulator of T helper 17 differentiation with important consequences on the protection against the extracellular bacteria Streptococcus pneumoniae following immunization in an infectious mouse model. Our projects also involve tight collaborations with the clinical departments of the Medical University of Vienna in view of translational applications.

More information about my laboratory, lab members are research projects can be found <here>.